We now know that the simple calculations underlying the old weight loss guidelines are fatally flawed because they fail to consider declining energy expenditure with weight loss26. Pharmacology, College of Medicine, The University of Tennessee Health Science Center, USA, Vania Calandrini German Research School for Simulation Sciences, Germany, William Cannon Pacific Northwest National Laboratory, USA, Jianshu Cao Massachusetts Institute of Technology, USA, Marco Capitanio University of Florence, Italy, Francesco Cardarelli Scuola Normale Superiore, Italy, Vincenzo Carnevale Temple University, USA, Laura Cella National Research Council (CNR), Italy, Jeffrey Chalmers The Ohio State University, USA, Yi-Fan Chen National Central University, Taiwan, Shi-Jie Chen University of Missouri-Columbia, USA, Alexandre Chenal Institut Pasteur, France, Salvatore Chiantia University of Potsdam, Inst. Such considerations would include employing systematic control of dosing, standardization of both research and treatment methodologies, and improved diagnostics of psychiatric disorders to test more homogeneous groups of patients, as well as careful selection and matching of patient and control groups (or conditions) being tested. Allen (third from right) and Rutan (fifth from right) were awarded the Ansari X PRIZE by members of the X PRIZE Foundation in November 2004. 's son), Solon M. Langworthy, John Howard, and Shegataro Morikubo. In one open-label study, 16 patients who met DSM-IV criteria for a recurrent major depressive disorder with a seasonal (winter) pattern were treated with light therapy for 2 weeks. [73], Allen purchased the Portland Trail Blazers NBA team in 1988 from California real estate developer Larry Weinberg for $70million. 's methods and philosophy and made every effort to regain control of chiropractic. Palmer continued to develop his techniques from Oregon. were "straight" and disdained the use of instruments, some early chiropractors, whom B.J. He had a multi-billion dollar investment portfolio, including technology and media companies, scientific research, real estate holdings, private space flight ventures, and stakes in other sectors. Portland, OR: 2017. For patients with BMI greater than 30 kg/m2 (or 2730 kg/m2 with obesity-related comorbid conditions), obesity pharmacotherapy leads to as much as 15% weight loss in responders, with weight loss being maintained in several studies for several years9092. Formal theory. Not to mention the standard management processes for large enterprises, including infrastructure, people, security, and marketing. [6][pageneeded] By the mid 1990s there was a growing scholarly interest in chiropractic. In total, Allen donated $500million to the institute, making it his single largest philanthropic recipient. Chemical Pathology, The Chinese University of Hong Kong, China, Kevin Woollard Imperial College London, UK, Marcin Wysoczynski Univeristy of Louisville, USA, Zhengguo Xiao University of Maryland, USA, Vijay Yadav National Institute of Immunology, India, Fumiichiro Yamamoto Institut de Medicina Predictiva i Personalitzada del Cncer, Spain, Otto Orlean Yang Geffen School of Medicine at University of California Los Angeles, USA, Samantha Yeligar Emory University / Atlanta VA Health Care System, USA, Di Yu Australian National University, Australia, Xiao-Qiang Yu University of Missouri-Kansas City, USA, Zhihong Yuan Emory University School of Medicine, USA, maurizio zanetti university of california, san diego, USA, Mingzhao Zhu Institute of Biophysics, Chinese Academy of Sciences, China, Aldert Zomer Utrecht University, The Netherlands, Jun Zou The First Affiliated Hospital of Soochow University, China, Juan Carlos Zuniga-Pflucker University of Toronto, Canada, Laith Abu-Raddad Weill Cornell Medical College Qatar, Cornell University, Qatar, Shaw Akula Brody School of medicine at East Carolina University, USA, Soren Alexandersen Deakin University and Geelong Centre for Emerging Infectious Diseases, Australia, Hossam Ashour University of South Florida, USA, Alessandra Bandera IRCCS Ca' Granda Ospedale Maggiore Policlinico Foundation, Italy, Anna Bershteyn New York University Grossman School of Medicine, USA, Khalid Beshir London School of Hygiene and Tropical Medicine, UK, Jason Blackburn University of Florida, USA, Tim Booth National Microbiology Laboratory, Canada, Nagihan Bostanci Karolinska Institutet, Sweden, Klaus Brandenburg Forschungszentrum Borstel, Germany, Veronica Briz Institute of Health Carlos III, National Center of Microbiology, Spain, Girbe Buist University of Groninger, The Netherlands, Marta Bull Seattle Children's Research Institute, USA, Cecilia Cabrera Institut de Recerca de la Sida IrsiCaixa, Spain, Adriana Calderaro Universit degli Studi di Parma, Italy, Crispim Cerutti Jr Federal University of Espirito Santi, Brazil, Carlos Chaccour ISGlobal Barcelona Institute for Global Health, Spain, Hui-Wen Chang National Taiwan University, Taiwan, Catherine Chapon CEA, Universit Paris-Sud 11, Inserm U1184, France, Hui-Wen Chen National Taiwan University, Taiwan, Sheng Chen The Hong Kong Polytechnic University, Hong Kong, Jack Chen University of Alaska Fairbanks, USA, Justin Jang Hann Chu National University of Singapore, Singapore, Michael Conway Central Michigan University College of Medicine, USA, Lindsey Crawford University of Nebraska-Lincoln, USAUniversity of Nebraska-Lincoln, USA, Krystyna Cwiklinski Queens University Belfast, UK, Xavier Didelot Imperial College London, UK, Joakim Dillner Karolinska Institutet, Sweden, Tania Dottorini University of Nottingham, UK, Susanna Dunachie University of Oxford, UK, Nazira El-Hage Florida International University, USA, Anna-Bella Failloux Institut Pasteur, France, Joseph Falkinham Department of Biological Sciences, Virginia Tech, USA, Delmiro Fernandez-Reyes University College London, UK, Eloisa Ferro Federal University of Uberlandia, Brazil, Laura Forsberg White Boston University, USA, Nicholas Furnham London School of Hygiene and Tropical Medicine, UK, Manoj Gambhir Monash University, Australia, Thomas Geisbert University of Texas Medical Branch, USA, Ron Geller Universitat de Valencia, Spain, Anna Maria Geretti University of Liverpool, UK, Tarik Gheit Infections and Cancer Biology group (IARC/Lyon/ France), France, Evangelos Giamarellos-Bourboulis National and Kapodistrian University of Athens, Medical School, Greece, Linnie Golightly Weill Cornell Medicine, USA, Harleen Grewal University of Bergen, Haukeland University Hospital, Norway, Andrea Groene Utrecht University, Pathology, Dutch Wildlife Health Centre, The Netherlands, Melissa Herbst-Kralovetz University of Arizona, USA, Grant Hill-Cawthorne University of Sydney, Australia, Deirdre Hollingsworth University of Warwick, UK, Yasuhiko Horiguchi Osaka University, Japan, Jaroslav Hrabak Charles University, Czech Republic, Li-Min Huang National Taiwan University, Taiwan, Victor Huber University of South Dakota, USA, Jameel Inal London Metropolitan university, UK, Daisuke Ishibashi Fukuoka University, Japan, Pooja Jain Drexel University College of Medicine, USA, Tao Jin Dept. Rosenbaum M, Hirsch J, Gallagher DA, Leibel RL. However, even small amounts of sustained weight loss lead to clinical health improvements and risk factor reductions. Join the discussion about your favorite team! Few people lose that much weight and keep it off for three years. The Public Library of Science and BioMed Central are prominent examples of this model. L-tryptophan (i.e. She joined Scientific Reports in January 2019. Palmer, adjusting the spine is the cure for all diseases for the human race. vs. AMA, the suit brought by Chester Wilk, D.C., of Illinois and five co-plaintiffs against the AMA and several co-defendants. Med Clin North Am. Delgado PL, Charney DS, Price LH, et al. Anecdotal descriptions estimate a height of roughly 1.82.7 metres (69 ft), with some descriptions having the creatures standing as tall as 3.04.6 metres (1015 ft). [41] Some chiropractors believe in Innate Intelligence, a faith-based, unscientific belief which has been a source of derision for chiropractors. He was the seventh and last child of Samuel Ogden Edison Jr. (18041896, born in Marshalltown, Nova Scotia) and Nancy Matthews Elliott (18101871, born in Chenango County, New York). The ability to change the rates of serotonin synthesis is the foundation of a large body of research examining the relationship of serotonin dysregulation to mood, behavior, and cognition. Although it has the lowest concentration in the human body relative to the other 19 primary amino acids, tryptophan is a critical component of numerous metabolic functions. Future studies that use multiple behavioral measures in the same experimental sample may clarify these conflicting findings.174. Pardridge WM, Oldendorf WH. Genètica, Fac. Mood and memory effects were specific to tryptophan depletion, which would seem to rule out general inhibition of protein synthesis that would also likely impair mood and memory functions. Carpenter LL, Anderson GM, Pelton GH, et al. In January 2016, it was reported that Tatoosh allegedly damaged coral in the Cayman Islands. Previously, he was the Editor-in-Chief of Engineering Reports. Kumar Cleveland State University, USA, Yingcheng Lai Arizona State University, USA, Renaud Lambiotte University of Oxford, UK, Luca Leuzzi Institute of Nanotechnology, NANOTEC-CNR, France, Jr-Shin Li Washington University in St. Louis, USA, Yang Li Northeast Electric Power University, China, Xiangtao Li Northeast Normal University, China, Jianguo Liu University of Shanghai for Science and Technology, China, Toktam Mahmoodi King's College London, UK, Hernan Makse City College of New York, USA, Cristina Masoller Universitat Politecnica de Catalunya, Spain, Tijana Milenkovic University of Notre Dame, USA, Rosario Morello University "Mediterranea" of Reggio Calabria, Italy, Yamir Moreno University of Zaragoza, Spain, Paolo Moretti Universitt Erlangen-Nrnberg, Germany, Sarah Muldoon University at Buffalo, SUNY, USA, Miguel ngel Muoz University of Granada, Spain, Masataka Nagaoka NagoyaUniversity, Japan, Juan-Pablo Ortega Nanyang Technological University, Singapore, Gergely Palla Etvs Lornd University, Hungary, Matjaz Perc University of Maribor, Slovenia, Walter Quattrociocchi Sapienza University of Rome, Italy, Miguel Romance Rey Juan Carlos University, Spain, Angel Snchez Universidad Carlos III de Madrid, Spain, Francisco Santos University of Lisbon, Portugal, Jeffrey Schenker Michigan State University, USA, Jean-Marc Schwartz University of Manchester, UK, Supratim Sengupta Indian Institute of Science Education and Research, Kolkata, India, Surajit Sengupta Tata Institute of Fundamental Research, India, Kieran Sharkey University of Liverpool, UK, Takashi Shimada University of Tokyo, Japan, Julian Sienkiewicz Warsaw University of Technology, Poland, Dimitra Simeonidou University of Bristol, UK, Ramesh Singh Indian Institute of Technology Bombay, India, Dmitry Smirnov Russian Academy of Sciences, Russia, Chaoming Song Northeastern University, USA, Tiziano Squartini IMT School for Advanced Studies, Italy, Aneta Stefanovska Lancaster University, UK, Attila Szolnoki Hungarian Academy of Sciences, Hungary, Bosiljka Tadic Jozef Stefan Institute, Slovenia, Misako Takayasu Tokyo Institute of Technology, Japan, Kazuhiro Takemoto Kyushu Institute of Technology, Japan, Mohd Tariq Aligarh Muslim University, India, Stefan Thurner Medical University of Vienna, Austria, Joaqun Torres Institute Carlos I for Theoretical and Computational Physics, University of Granada, Spain, Eleni Vasilaki University of Sheffield, UK, Athanasios Vasilakos Lule University of Technology, Sweden, Julian Vicens Eurecat-Technology Centre of Catalonia, Spain, Nikolaos Voulgarakis Washington State University, USA, Shaohua Wan Zhongnan University of Economics and Law, China, Huijuan Wang Delft University of Technology, The Netherlands, Qingsong Wang University of Science and Technology of China, China, Youqing Wang Beijing University of Chemical Technology, China, Ronald White James Cook University, Australia, Gongnan Xie Northwestern Polytechnical University, China, Zhenya Yan Academy of Mathematics and Systems Science, Chinese Academy of Sciences, China, Serhiy Yanchuk Humboldt University of Berlin, Germany, Kuo-Ching Ying National Taipei University of Technology, Taiwan, Yongguang Yu Beijing Jiaotong University, China, Yi Zhao Harbin Institute of Technology, China, Zhi-Gang Zheng College of Information Science and Technology, Institute of Systems Science, Huaqiao University, China, Changsong Zhou Hong Kong Baptist University, Hong Kong, Haijun Zhou Institute of Theoretical Physics, Chinese Academy of Sciences, China, Marinka Zitnik Harvard Medical School, USA, Micha Zochowski University Michigan, USA, Iker Zuriguel Universityof Navarra, Spain, Chihiro Akazawa Tokyo Medical and Dental University, Japan, Shigeki Arawaka Division of Neurology, Department of Internal Medicine IV, Osaka Medical College, Japan, Qadeer Arshad Imperial college London, UK, Eishi Asano Children's Hospital of Michigan, Wayne State University, USA, Francesca Baglio Fondazione Don Carlo Gnocchi IRCCS, Italy, David Bartrs-Faz University of Barcelona, Spain, Christoph Beier University of Southern Denmark, Denmark, Ferdinand Binkofski University Hospital RWTH Aachen, Germany, Wolfgang Boehmerle Charit - Universittsmedizin Berlin, Germany, Barbara Borroni University of Brescia, Italy, Elisabeth Chroni Neurology Department, University Hospital & Medical School, University of Patras, Greece, Stefania Corti University of Milan, Italy, Yuri Costa Piracicaba Dental School, University of Campinas, Brazil, Thanh Dang-Vu Concordia University, Canada, Kumlesh Kumar Dev Trinity College Dublin, Ireland, David Devos University of Lille, INSERM U1171, University hospital of Lille, France, Jordi Diaz-Manera Neuromuscular disorders Unit. [48] In 1975, an anonymous AMA insider describing himself as a disgruntled AMA staffer and identifying himself as "Sore Throat" released information concerning the Committee on Quackery and its proposed methods to eliminate chiropractic to the press. Predictive value of tryptophan/large neutral amino acid ratio to antidepressant response. Serotonergic studies in patients with affective and personality disorders: Correlates with suicidal and impulsive aggressive behavior. Synthesis and release of serotonin by brain slices: Effect of ionic manipulations and cationic ionophores. Its content included obituaries of famous men, church history, and legal reports. Using a competitive reaction time test, tryptophan depletion increased impulsive aggression of the low impulsive group, but not the high impulsive group.175 The authors suggested that the lack of effect in the high impulsive group was likely due to the difficulty of increasing already high rates of impulsivity that could not be further influenced by reduced serotonin, whereas the depletion effect could make the low impulsive group react as if they were high impulsive. On July 18, 2015, Ischia Global Film and Music Festival recognized Allen with the Ischia Humanitarian Award. Rapid depletion of plasma tryptophan: A review of studies and experimental methodology. Jquier E, Lovenberg W, Sjoerdsma A. Tryptophan hydroxylase inhibition:The mechanism by which p-chlorophenylalanine depletes rat brain serotonin. The global obesity pandemic: shaped by global drivers and local environments. Menstrual cycle effects on the metabolism of tryptophan loads. Oregon (/ r n / ()) is a state in the Pacific Northwest region of the Western United States.The Columbia River delineates much of Oregon's northern boundary with Washington, while the Snake River delineates much of its eastern boundary with Idaho.The 42 north parallel delineates the southern boundary with California and Nevada.. Oregon has been home to many However, the United States' output dropped from 52.3% to 49.4% of the world's total, and its portion of the top one percent dropped from 65.6% to 62.8%. Volpp KG, John LK, Troxel AB, Norton L, Fassbender J, Loewenstein G. Financial incentive-based approaches for weight loss: a randomized trial. [38] His cancer was successfully treated by several months of radiation therapy,[35] Allen was diagnosed with non-Hodgkin lymphoma in 2009. Palmer gave the first chiropractic adjustment to Harvey Lillard, on September 18, 1895. Discover National Geographic Live events, featuring our world-renowned Explorers, photographers, scientists, filmmakers, and adventurers. Both professed the use of spinal manipulation on joint dysfunction/subluxation to improved health. Chiropractors were jailed for "practicing medicine without a license" which the profession designed a legal and political defence against prosecution arguing that chiropractic was "separate and distinct from medicine", asserting that chiropractors "analyzed" rather than "diagnosed", and "adjusted" subluxations rather than "treated" disease. Knowler WC, Barrett-Connor E, Fowler SE, et al. Acute tryptophan depletion aggravates premenstrual syndrome. Some alleged observations describe Bigfoot as more "man-like", with Vanvitelli', Italy, Maja Cemazar Institute ofo Oncology Ljubljana, Slovenia, Debanjan Chakroborty Ohio State University, USA, Dhyan Chandra Roswell Park Cancer Institute, USA, Eric Chang Baylor College of Medicine, USA, Wen-Wei Chang Department of Biomedical Sciences, Chung Shan Medical University, Taiwan, Wun-Shaing Chang National Health Research Institutes, Taiwan, Guoan Chen Southern University of Science and technology, China, Dongquan Chen UNIVERSITY OF ALABAMA AT BIRMINGHAM, USA, Kwok-Leung Cheung University of Nottingham, UK, Arvind Chhabra University of Connecticut Health Center, USA, Natsuko Chiba Department of Cancer Biology, Institute of Development, Aging and Cancer, Tohoku University, Japan, Ming-Hsien Chien Taipei Medical University, Taiwan, Jeremy Chien University of Kansas Medical Center, USA, Je-Yoel Cho Department of Biochemistry, College of Veterinary Medicine, Seoul National University, South Korea, Sungdae Cho Seoul National University, South Korea, Sunga Choi Chungnam National University, South Korea, Sherri Christian Memorial University of Newfoundland, Canada, Eric Chuang National Taiwan University, Taiwan, Kuo-Hsiang Chuang Taipei Medical University, Taiwan, Jeffrey Chuang The Jackson Laboratory for Genomic Medicine, USA, Nicholas Clemons Peter MacCallum Cancer Centre, Melbourne, Australia, Spencer Collis University of Sheffield, UK, Jose Costoya Universidade de Santiago de Compostela, Spain, Charlotta Dabrosin Linkping University, Sweden, Chendil Damodaran University of Louisville, USA, Ramanuj Dasgupta Genome Institute of Singapore, Singapore, Melissa Davis Weill Cornell Medicine, United States, Waldemar Debinski Wake Forest University School of Medicine, USA, Gagan Deep Wake Forest Baptist Medical Center, USA, David DeGraff Pennsylvania State University College of Medicine, USA, Paul Dent Virginia Commonwealth University, USA, Grant Dewson Walter & Eliza Hall Institute of Medical Research, USA, Danny Dhanasekaran Stephenson Cancer Center, University of Oklahoma Health Sciences Center, USA, Sandra Martha Gomes Dias Brazilian National Laboratory for Biosciences, Brazil, Manjusha Dixit National Institute of Science Education and Research, India, Xiaoqun Dong University of Oklahoma Health Sciences Center, USA, Xiaoqun Dong University of Rhode Island, USA, Stefan Duensing Department of Urology, University of Heidelberg, Germany, Miriam Dwek University of Westminster, UK, Michael Eccles University of Otago, New Zealand, Richard Eckert University of Maryland School of Medicine, USA, Pieter Eichhorn Curtin University, Australia, Martyna Elas Jagiellonian University, Faculty of Biochemistry, Biophysics and Biotechnology, Poland, Hitoshi Endo Center for Molecular Prevention and Environmental Medicine, Department of Preventive Medicine, Japan, Adriana Eramo Istituto Superiore di Sanit, Italy, Marc Ernstoff Roswell Park Comprehensive Cancer Center, USA, Farzad Esni University of Pittsburgh, USA, Jiangli Fan Dalian University of Technology, China, Bingliang Fang MD Anderson Cancer Center, USA, Jose Fernandez-Luna Valdecilla University Hospital, Spain, Fabian Filipp University of California, Merced, USA, Carmela Fimognari University of Bologna - Department for Life Quality Studies, Italy, Melissa Fishel Indiana University School of Medicine, USA, Hermann Frieboes University of Louisville, USA, Steven Frisch West Virginia University, USA, Gilbert Fruhwirth Kings College London, UK, Naoya Fujita Japanese Foundation for Cancer Research, Japan, Simone Fulda Institute for Experimental Cancer Research in Pediatrics, Germany, Saori Furuta University of Toledo Health Science Campus, USA, Reynaldo Garcia University of the Philippines Diliman, Philippines, Jess Garca-Foncillas Jimnez Daz Foundation, Spain, Kevin Gardner National Cancer Institute, NIH, USA, Neha Garg Banaras Hindu University, India, Patrizia Gazzerro University of Salerno, Italy, Yubin Ge Department of Oncology, Wayne State University School of Medicine, USA, David Gewirtz Virginia Commonwealth University, USA, Sunita Ghosh University of Alberta, Canada, Daniele Gilkes Johns Hopkins University, USA, Elisa Giovannetti VU University Medical Center, The Netherlands, Enrico Giraudo Candiolo Cancer Institute, Italy, Ravindran Caspa Gokulan Sylvester Comprehensive Cancer Center, University of Miami, USA, Susumu Goyama The Institute of Medical Science, Tokyo University, Japan, Elin Gray Edith Cowan University, Australia, Jian Gu University of Texas MD Anderson Cancer Center, USA, Haihua Gu Wenzhou Medical University, China, Francisco Guilln Grima Clinica Universitaria de Navarra, Spain, Subash Chandra Gupta Banaras Hindu University, Varanasi, India, Sanjeev Gupta National University of Ireland, Galway, Republic of Ireland, Mahmood Hachim Mohammed Bin Rashid University Of Medicine and Health Sciences, UAE, Adriana Haimovitz-Friedman Memorial Sloan Kettering Cancer Center, USA, Ryuji Hamamoto Tokyo Medical and Dental University, Japan, Wonshik Han Seoul National University College of Medicine, Republic of Korea, Joshua Harrell Virginia Commonwealth University, USA, Maria Hatziapostolou Nottingham Trent University, UK, Tong-Chuan He The University of Chicago Medical Center, USA, Alfredo Hidalgo-Miranda Cancer Genomics Laboratory, National Institute of Genomic Medicine, Mexico, Michelle Hildebrandt UT MD Anderson Cancer Center, USA, Richard Hill University of Portsmouth, UK, Mitchell Ho National Cancer Institute, NIH, USA, Ann Hopkins Royal College of Surgeons in Ireland, Ireland, Carrie House San Diego State University, USA, Michael Hsiao Genomics Research Center, Academia Sinica, Taiwan, Peter Huber German Cancer Research Centre, Germany, Wen-Chun Hung National Health Research Institutes, Taiwan, Tabish Hussain UT MD Anderson Cancer Center, USA, Rosa Hwang University of Texas MD Anderson Cancer Center, USA, Seock-Ah Im Cancer Research Institute, Seoul National University, South Korea, Jun-ichiro Inoue Institute of Medical Science, The University of Tokyo, Japan, Natalia Isaeva Yale School of Medicine, USA, Ping Ji The University of Texas MD Anderson Cancer Center, USA, Masahito Jimbo University of Michigan, USA, Rachelle Johnson Vanderbilt University Medical Center, USA, ngeles Juarranz Department of Biology, Autonomous University of Madrid, Spain, Daehee Kang Seoul National University College of Medicine, Republic of Korea, Ka-Won Kang Korea University, Republic of Korea, Sudeshna Kar Jamia Hamdard University, India, Toyomasa Katagiri Tokushima University, Japan, Yukinari Kato Tohoku University School of Medicine, Japan, Lev Kats Peter MacCallum Cancer Centre, Melbourne, Australia, Marcelo Kazanietz Perelman School of Medicine, University of Pennsylvania, USA, Ameeta Kelekar University of Minnesota, USA, Mark Kelley Indiana University School of Medicine, USA, Santosh Kesari John Wayne Cancer Institute, USA, Yun Hak Kim Pusan National University, South Korea, Hangun Kim Sunchon National University, South Korea, Hyeon Ho Kim Sungkyunkwan University/Samsung Medical Center,, South Korea, Mihwa Kim University of Texas Rio Grande Valley, USA, Carolyn Klinge University of Louisville School of Medicine, USA, Ruth Kluck Walter & Eliza Hall Institute of Medical Research, Australia, Motohiro Kojima National Cancer Center, EPOC, Japan, Vamsi Kota Georgia Cancer Center at Augusta University, USA, Hari Koul Louisiana University Health Sciences Center, USA, Constantinos Koumenis University of Pennsylvania, USA, Victor Krasnykh MD Anderson Cancer Center, USA, Marco Krengli University of Piemonte Orientale, Italy, Marina Kriajevska University of Leicester, UK, Rakesh Kumar George Washington University, USA, Arun Kumar Indian Institute of Science, India, Peeyush Lala University of Western Ontario, Canada, Tobias Lange University Medical Center Hamburg-Eppendorf, Germany, Eric Lau H. 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