Other drug-related side effects observed during in-clinic titration and home treatment include swelling of leg veins, leg pain, perineal pain, and rapid pulse, each occurring in < 2% of patients. What is this medicine? The active compound in intraurethral MUSE is alprostadil, a prescription medication that expands blood vessels and increases blood flow in the body, . this savings card may be used to reduce the amount of your out-of-pocket costs for muse (alprostadil) urethral suppository up to a maximum of $50 per 30-day prescription after you pay the first $20 per 30-day prescription for the first fill, and then for subsequent fills, up to a maximum of $50 per 30-day prescription after you pay the first Note: Call your doctor promptly if you have a rigid erection that lasts more than 4 hours. The suppository form is not as effective. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. PHARMACEUTICALS MUSE should not be used more than twice per day. Your doctor will teach you how to give yourself the injection. Who should not take Alprostadil Suppository? There are several causes, the most common being due to a narrowing of the arteries that take blood to the penis. Please read this pamphlet before using MUSE (alprostadil). Although unreported in clinical trials, there is the possibility that an overdosage of MUSE can cause priapism, a painful erection of the penis sustained for hours and unrelieved by sexual intercourse or masturbation. Alcohol or marijuana (cannabis) can make you more dizzy. You can get alprostadil injected directly into the penis. This site complies with the HONcode standard for trustworthy health information: verify here. Patients and partners who use MUSE should be counseled about the protective measures that are necessary to guard against the spread of sexually transmitted agents, including the human immunodeficiency virus (HIV). This survey is being conducted by the WebMD marketing sciences department. Injectable alprostadil is sold under the brand names Caverject, Edex, and Prostin VR. Do not reuse them! You should not use MUSE if you have any of the following: WHAT ARE THE POSSIBLE SIDE EFFECTS OF MUSE? It produces an erection in about 30%-40% of men with ED. The use of a water-based lubricant may facilitate vaginal penetration. Keep unopened medicine in the pouch. How to use Alprostadil Suppository Read the Patient Information Leaflet provided by your pharmacistbefore you start using alprostadiland each time you get a refill. This medicine does not provide birth control. It works by relaxing the blood vessels and muscles in the penis. During post-marketing surveillance syncope occurring within one hour of administration has been reported. ALPROSTADIL (al PROS ta dil) is a natural protein. Talk to your health care provider about the use of this medicine in children. After you have administered MUSE, it is important to sit, or preferably stand or walk about for 10 minutes while the erection is developing. Alprostadil is also used to improve blood flow in . Because of the potential for these side effects, MUSE titration should be carried out under medical supervision. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use. We do not endorse non-Cleveland Clinic products or services. ALPROSTADIL SUPPOSITORY - PENILE. ADDITIONAL INFORMATION AND PRACTICAL TIPS. Learn all usage instructions in the product package. This condition is serious and, if untreated, it can lead to permanent inability to have an erection. Wash your hands before and after use. This drug is not right for everyone. The most common drug-related adverse event reported by female partners during placebo-controlled clinical studies was vaginal burning/itching, reported by 5.8% of partners of patients on active vs. 0.8% of partners of patients on placebo. Alprostadil concentrations of 400 mcg/mL had no effect on human sperm motility or viability in vitro. After my erection is over, will my penis feel sensitive? By expanding blood stream to the penis, alprostadil assists speed up an erection. The active ingredient in MUSE is alprostadil, which is chemically identical to the naturally occurring eicosanoid, prostaglandin E1 (PGE1). Some patients may experience some mild pain and aching in the penis or groin area. The most notable systemic effects of alprostadil are vasodilation, inhibition of platelet aggregation, and stimulation of intestinal and uterine smooth muscle. The Bottom Line: Sildenafil (Viagra) vs Intra-Urethral MUSE Suppository. The MUSE applicator (Fig.1) contained in each foil pouch is intended for 1 administration only. Patients with pulmonary disease therefore may have a reduced capacity to clear the drug. Please read patient instruction leaflet regarding usage and storage. Wait 10-30 minutes before you have sex. Canada residents can call a provincial poison control center. Gently insert the suppository into the anus, narrow end first. Talk with the doctor. WHAT ARE THE POSSIBLE SIDE EFFECTS OF MUSE FOR YOUR PARTNER? As the expanded corporal sinusoids are compressed against the tunica albuginea, venous outflow through subtunical vessels is impeded and penile rigidity develops. If my erection lasts longer than desired, what should I do? include protected health information. Also, your erection may continue after orgasm. In studies of sexual performance, patients were screened in the clinic, generally using doses of 125 mcg to 1000 mcg, for a satisfactory erectile response, then sent home with the selected dose or placebo for evaluation of sexual performance. There is no information on the effects on early pregnancy of PGE1 at the levels received by female partners. Alprostadil (Muse) received an overall rating of 9 out of 10 stars from 4 reviews. WHAT ARE THE POSSIBLE SIDE EFFECTS OF MUSE?. If we combine this information with your protected In the very unlikely event you have a painful or prolonged erection lasting 4 or more hours, stop using this drug and seek immediate medical attention, or permanent problems could occur. In a study of 14 subjects, the plasma PGE1 level was shown to be undetectable within 60 minutes of MUSE administration in most subjects. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. Please review the video and patient starter booklet available from your doctor which illustrates various positions that will enhance your erection. Intravenous doses of 1 to 10 micrograms per kilogram of body weight lower blood pressure in mammals by decreasing peripheral resistance. The mean total endogenous PGE content (PGE1, PGE2, 19-OH-PGE1, and 19-OH-PGE2) of the ejaculate in these subjects was 444 mcg (range 0-1423 mcg). If you have any additional questions about MUSE, please call the toll free patient information line at Meda Pharmaceuticals Inc. 1-888-367-MUSE (1-888-367-6873), or visit the MUSE product web site, http://www.muserx.net, Distributed by: Do not freeze. Uses of Alprostadil Urethral Suppository: It is used to treat erectile dysfunction (ED). Read the Patient Information Leaflet provided by your pharmacist before you start using alprostadil and each time you get a refill. Keep all medicines away from children and pets. Somerset, New Jersey 08873-4120. http://www.muserx.net Catalog Number: 05-10-00000FIS-1001-04Revised: 4/20182018 Mylan Specialty L.P. MUSE Policy, Get useful, helpful and relevant health + wellness information, 9500 Euclid Avenue, Cleveland, Ohio 44195 |, Visitation, mask requirements and COVID-19 information. Do not open until you are ready to use it. If you have an allergy to alprostadil or any other part of alprostadil urethral suppository. Alprostadil urethral suppository is used to treat men who have erectile dysfunction (also called sexual impotence). information and will only use or disclose that information as set forth in our notice of When used via a suppository, it works the same way as when it is injected. Before using alprostadil, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. Alprostadil is a common medication for erectile dysfunction treatment. The drug promotes the flow of blood towards the penis. If you have questions, ask your doctor or pharmacist. Your partner may want to consult her health care provider if she has not had sexual intercourse for an extended period of time. US residents can call their local poison control center at 1-800-222-1222. If your erection cannot be maintained for the time needed to have foreplay and sexual intercourse, you may need to have your dose increased. The mean maximum plasma PGE1 concentration following intraurethral administration of the highest dose of MUSE (1000 mcg) was barely detectable (11.4 picograms/mL). In the 2 largest double-blind, parallel, placebo-controlled trials, 1511 patients received MUSE at least 1 time in the clinic setting. Set the bottles on a clean surface. See what others have said about Alprostadil (Muse), including the effectiveness, ease of use and side effects. Not all patients beginning titration had a successful dose and some patients could not tolerate MUSE, principally because of penile pain, so that the success rates in the studies described below must be understood to represent response rates only in patients who were successfully titrated. Alprostadil injection and suppositories are used to treat certain types of erectile dysfunction (impotence; inability to get or keep an erection) in men. It is recommended that couples using MUSE employ adequate contraception if the female partner is of childbearing potential. (al-PROS-ta-dil) COMMON BRAND NAME (S): Muse. What are the side effects associated with MUSE? Push the button on the applicator to deliver the suppository into the urethra. Before using this medicine, consult your doctor or pharmacist if you have: genito-urinary tract disorder (such as urethral stricture/obstruction, urethritis, inflammation/infection of the head of the penis), indwelling urethral catheter. MUSE is indicated for the treatment of erectile dysfunction. The name MUSE is an acronym for Medicated Urethral System for Erection. You can begin sexual activity, but having the man lie down, especially on his back shortly after administration, is not recommended. This video reviews Alprostadil (Caverject) and honestly looks at the pros and cons of using Caverject for Erectile Dysfunction.#alrpostadil #cav. This medicine causes an erection because it increases the blood flow to the penis. How do I know if I have the correct dose of MUSE? Minor/Significance Unknown. There are no other active agents or excipients in MUSE. Medical information line at Meda Pharmaceuticals Inc. 1-888-345-MUSE (1-888-345-6873). information highlighted below and resubmit the form. privacy practices. MUSE is designed to deliver alprostadil directly to the urethral lining for transfer via the corpus spongiosum to the corpora cavernosa. WebMD does not provide medical advice, diagnosis or treatment. Before you draw the medicine into the syringe, wash your hands with soap and water. The small amount of urine left in the urethra will help dissolve the suppository. HOW TO USE: Read the Patient Information Leaflet provided by your pharmacist before you start using alprostadil and each time you get a refill. This medicine helps to create and maintain an erection. Do not use MUSE more than twice in a 24-hour period. The half-life of alprostadil in humans is short, varying between 30 seconds and 10 minutes, depending on the body compartment in which it is measured and the physiological status of the subject. Properly discard this product when it is expired or no longer needed. 2005 - 2022 WebMD LLC. In vitro, alprostadil (PGE1) has been shown to cause dose-dependent smooth muscle relaxation in isolated corpus cavernosum and corpus spongiosum preparations. What will the erection be like? Alprostadil is suspended in polyethylene glycol 1450 (as excipient) and is formed into a medicated pellet (micro-suppository measuring 1.4 mm in Patients should be individually titrated to the lowest dose that is sufficient for sexual intercourse. (See WARNINGS). This medicine is not for regular use. The risk of priapism (erections that last too long) aren't just a matter of "overdosing." It can happen with the normally accepted dose regardless of the manner in which it is delivered. If you experience dizziness or feel faint during sexual intercourse, this may be due to low blood pressure. In women, mild vaginal itching and burning have been observed. When traveling, store this medicine in a portable ice pack or cooler. masters in marketing south korea. Its solubility at 35C is 8000 mcg per 100 mL double-distilled water. Priapism can result in permanent worsening of erectile function. This medicine causes an erection because it increases the blood flow to the penis. the unsubscribe link in the e-mail. Viagra is usually the preferred first treatment option for men with impotence. No. The maximum frequency of use is 2 administrations per 24-hour period. However, the actual duration will vary from patient to patient. Alprostadil is in a class of medications called vasodilators. It widens your blood vessels and relaxes the muscles around your penis. information submitted for this request. Save on Alprostadil at your pharmacy with the free discount below. Limit alcoholic beverages. This medicine is used for a short time until the condition can be corrected. Does Alprostadil Suppository interact with other drugs you are taking? Report . Additionally, vasodilation has been demonstrated in isolated cavernosal artery segments that were pre-contracted with either norepinephrine or prostaglandin F2. If you notice other effects not listed above, contact your doctor or pharmacist. All rights reserved. It is important to sit, stand or walk about for 10 minutes after administration. MUSE is intended for single-dose application only. MUSE should be administered as needed to achieve an erection. Drug information provided by: IBM Micromedex. MUSE is available in 4 dosage strengths: 125 mcg, 250 mcg, 500 mcg, and 1000 mcg. Each patient should be instructed by a medical professional on proper technique for administering MUSE prior to self-administration. It works by helping the blood flow into the penis to achieve and maintain an erection.This medication is not for use in women or children. To decrease your risk of infection, always use an effective barrier method such as a latex or polyurethane condom during all sexual activity. MUSE is contraindicated in men with any of the following: Because of the potential for symptomatic hypotension and syncope, which occurred in 3% and 0.4%, respectively, of patients during in-clinic dosing, MUSE titration should be carried out under medical supervision. The following table summarizes the frequency of adverse events reported by patients using MUSE or placebo. Intravaginal administration of up to 4000 mcg/day of MUSE (alprostadil) to pregnant rabbits (1100 mcg/kg/day or about 12.5 times the maximum recommended daily dose adjusted for body surface area) resulted in no evidence of harm to the fetus. Follow the directions on the label about where its OK to store it. The suppository contains the drug alprostadil, which has been available for several years as an intracavernous injection. Alprostadil urethral suppository. - Suppository - Suspension - Tablet - Tech Transfer - Topical - Vaginal / Rectal - Preformulation & Material Science - API Screening - Chiral Resolution Screening - Device . It belongs to a group of medicines called vasodilators that can increase blood flow by expanding blood vessels. It is recommended that you use a condom during sexual intercourse. Patients should be informed that MUSE offers no protection from the transmission of sexually transmitted diseases. Please note: This is a refrigerated product, and it can only be shipped using our EMS courier option. Before administering MUSE, please review the patient video and education booklet. Many people using this medication do not have serious side effects. Or you can use it as suppository, placing it into the opening at the tip of the penis. It is recommended that MUSE be stored in a refrigerator. CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals.
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